Overexpression of melanoma-associated antigen A2 has a clinical significance in embryonal carcinoma and is associated with tumor progression.

Leili Saeednejad ZanjaniMahdieh RazmiFahimeh FattahiElham KalantariMaryam AbolhasaniSima SakiZahra MadjdMonireh Mohsenzadegan

Published in: Journal of cancer research and clinical oncology (2021)

Our results confirm that increased nuclear expression of MAGE-A2 has a clinical significance in embryonal carcinomas and is associated with progression of disease. Moreover, MAGE-A2 may act as a potential predictive biomarker for the prognosis in embryonal carcinomas if follow-up period becomes longer. Further investigations for the biological function of MAGE-A2 are required in future studies.

Keyphrases

poor prognosis
high grade
cell proliferation
long non coding rna
transcription factor
current status
binding protein
human health
climate change