MicroRNA-378a-3p contributes to ovarian cancer progression through downregulating PDIA4.

Chanjiao YaoChen ChunyanQiu XiaoxinHan Youjian

Published in: Immunity, inflammation and disease (2020)

This study provides evidences that miR-378a-3p activates PI3K/AKT signaling pathway by modulating PDIA4 expression, thereby playing a role in promoting the growth of ovarian cancer cells. This study provides novel directions for targeted therapy of ovarian cancer.

Keyphrases

signaling pathway
pi k akt
poor prognosis
epithelial mesenchymal transition
induced apoptosis
cell death
endoplasmic reticulum stress