Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the developing human blood-brain barrier.
Phetcharawan LyeEnrrico BloiseStephen G MatthewsPublished in: Fluids and barriers of the CNS (2023)
Infectious PAMPs significantly modify the expression and function of MDR transporters in hfBECs, though effects are PAMP-, time- and dose-specific. In conclusion, bacterial and viral infections during pregnancy likely have profound effects on exposure of the fetal brain to physiological and pharmacological substrates of P-gp and BCRP, potentially leading to altered trajectories of fetal brain development.
Keyphrases
- blood brain barrier
- endothelial cells
- cerebral ischemia
- resting state
- white matter
- multidrug resistant
- sars cov
- functional connectivity
- depressive symptoms
- high glucose
- induced pluripotent stem cells
- multiple sclerosis
- vascular endothelial growth factor
- autism spectrum disorder
- long non coding rna
- pluripotent stem cells