Alpha-Fetoprotein Regulates the Expression of Immune-Related Proteins through the NF-κB (P65) Pathway in Hepatocellular Carcinoma Cells.

Qiu-Ting LiMeng-Jun QiuSheng-Li Yang Xiefan FangXiao-Xiao HeMeng-Meng WangYa-Nan LiZhi-Fan Xiong Shanshan Huang

Published in: Journal of oncology (2020)

AFP could enhance proliferation, invasion, and migration in HCC cells. The upregulation of AFP would increase the PD-L1 and B7-H4 mRNA and protein expression in HCC tissues through the upregulation and activation of the P65 protein.

Keyphrases

signaling pathway
poor prognosis
induced apoptosis
binding protein
pi k akt
cell cycle arrest
long non coding rna
cell proliferation
gene expression
cell migration
endoplasmic reticulum stress
cell death
inflammatory response
small molecule
drug induced