Programmable promoter editing for precise control of transgene expression.

Sneha R KabariaYunbeen BaeMary E EhmannAdam M BeitzBrittany A DornEmma L PetermanKasey S LoveDeon S PloesslKate E Galloway

Published in: bioRxiv : the preprint server for biology (2024)

DIAL offers an extensible framework for designing synthetic promoters that generate heritable setpoints of gene expression and performs across a range of cell types and delivery systems.

Keyphrases

gene expression
dna methylation
crispr cas
poor prognosis
single cell
cell therapy
transcription factor
binding protein
stem cells
bone marrow