Human Monoclonal IgE Antibodies-a Major Milestone in Allergy.

Scott A SmithMaksymilian ChruszczMartin D Chapman Anna Pomés

Published in: Current allergy and asthma reports (2022)

conformational epitope on Der p 2. This review provides an overview of this major milestone in allergy, the first atomic resolution structure of an authentic human IgE epitope. The molecular insights that IgE epitopes provide will allow for structure-based design approaches to the development of novel diagnostics, antibody therapeutics, and immunotherapies.

Keyphrases

endothelial cells
single molecule
induced pluripotent stem cells
pluripotent stem cells
small molecule
molecular dynamics
atopic dermatitis
molecular dynamics simulations
multiple myeloma
electron microscopy
allergic rhinitis