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Quorum-sensing molecule dihydroxy-2,3-pentanedione and its analogs as regulators of epithelial integrity.

Samira ElmanfiX MaHerman O SintimE KönönenS SyrjänenUlvi Kahraman Gursoy
Published in: Journal of periodontal research (2018)
The results indicate that isobutyl-DPD has the potential to enhance the integrity of the epithelium by stimulating the formation of occluding, without affecting the proliferation or gelatinolytic enzyme activities of the exposed cells. The modulatory effect of an AI-2 analog on the epithelial cell response is shown for the first time.
Keyphrases
  • induced apoptosis
  • signaling pathway
  • cell cycle arrest
  • artificial intelligence
  • transcription factor
  • molecular docking
  • endoplasmic reticulum stress
  • human health
  • cell proliferation
  • deep learning