Quorum-sensing molecule dihydroxy-2,3-pentanedione and its analogs as regulators of epithelial integrity.

Samira ElmanfiX MaHerman O SintimE KönönenS SyrjänenUlvi Kahraman Gursoy

Published in: Journal of periodontal research (2018)

The results indicate that isobutyl-DPD has the potential to enhance the integrity of the epithelium by stimulating the formation of occluding, without affecting the proliferation or gelatinolytic enzyme activities of the exposed cells. The modulatory effect of an AI-2 analog on the epithelial cell response is shown for the first time.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
artificial intelligence
transcription factor
molecular docking
endoplasmic reticulum stress
human health
cell proliferation
deep learning