Baclofen destabilises breathing during sleep in healthy humans: A randomised, controlled, double-blind crossover trial.

Christian StrausMarion TeulierSébastien MorelNicolas WattiezDavid HajageCaroline GiboinBeny CharbitEric DasqueLaurence BodineauBruno ChenuelNicolas StrausValérie AttaliCaroline Sévoz-Couche

Published in: British journal of clinical pharmacology (2020)

Baclofen did not stabilise breathing in our model. On the contrary, it increased respiratory variability. Baclofen should probably not be used in patients with or at risk of periodic breathing.

Keyphrases

double blind
study protocol
placebo controlled
phase iii
clinical trial
phase ii
open label
physical activity
randomized controlled trial