Immune signatures of checkpoint inhibitor-induced autoimmunity - a focus on neurotoxicity.

Leonie Müller-JensenAxel Ronald Schulz Henrik E Mei Raphael Mohr Claas Ulrich Philipp Knape Nikolaj Frost Stefan Frischbutter Désirée Kunkel Christian SchinkeLorena Ginesta RoqueSmilla K MaierhofFlorian T NickelLucie Heinzerling Matthias Endres Wolfgang Boehmerle Petra Huehnchen Samuel Knauss

Published in: Neuro-oncology (2023)

We demonstrate profound and partly subgroup-specific immune cell dysregulation in irAE-n patients, which may guide future biomarker development and targeted treatment approaches.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
dna damage
cell cycle
randomized controlled trial
diabetic rats
high glucose
genome wide
cancer therapy
drug induced
combination therapy
open label
phase iii
smoking cessation