Taf14 is required for the stabilization of transcription pre-initiation complex in Saccharomyces cerevisiae.

Kadri PeilHenel JürgensJohanna LuigeKersti KristjuhanArnold Kristjuhan

Published in: Epigenetics & chromatin (2020)

Lethality of YEATS-deficient cells can be rescued by the expression of truncated Taf14 protein lacking the entire YEATS domain, indicating that the YEATS domains are not required for cell survival. The YEATS domain of Taf14 participates in PIC stabilization and acetylated/crotonylated H3K9 is not the critical target of the Taf14 YEATS domain in vivo.

Keyphrases

saccharomyces cerevisiae
induced apoptosis
poor prognosis
binding protein
cell cycle arrest
cell death
protein protein
cell proliferation
wild type