Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.
Simon ErlendssonDustin R MoradoHarrison B CullenCedric FeschotteJason D ShepherdJohn A G BriggsPublished in: Nature neuroscience (2020)
Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.
Keyphrases
- high resolution
- structural basis
- genome wide
- genome wide identification
- cell adhesion
- transcription factor
- cerebral ischemia
- mass spectrometry
- electronic health record
- copy number
- dna methylation
- genome wide analysis
- gene expression
- machine learning
- dna binding
- disease virus
- high speed
- data analysis
- blood brain barrier
- deep learning