Influence of antenatal corticosteroid lung maturation on maternal inflammatory parameters.
Maria KastanekFlorian FrommletLara LinsenmeierHanns HelmerPublished in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2020)
The aim of this prospective study (Clinical Trials Identifier: NCT02993744) was to detect the effect of fetal lung maturation with betamethasone on the maternal inflammatory parameters C-reactive protein (CRP) and leukocytes. The blood results of 75 patients in the week of gestation (WOG) 23/0 to 34/6 under threat of preterm delivery and treated with betamethasone were analyzed. Sixty-five pregnant women without complications served as control group. Leukocyte numbers increased significantly about 2.4 thsd./µL (±3.3 standard deviation), with a confidence interval of 95% from 1.5 to 3.2 (p < .001). Calculations for CRP were done with logarithmized values. CRP decreased significantly (p < .001) by the factor 0.465, with a 95% confidence interval from 0.376 to 0.576. The results of this study can be used in clinical routine as a decision support, to come to conclusions about inflammatory processes during lung maturation.
Keyphrases
- pregnant women
- clinical trial
- pregnancy outcomes
- end stage renal disease
- oxidative stress
- newly diagnosed
- ejection fraction
- preterm birth
- birth weight
- chronic kidney disease
- peripheral blood
- prognostic factors
- peritoneal dialysis
- molecular dynamics
- randomized controlled trial
- body mass index
- weight loss
- study protocol
- open label