ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer.

Hao Liu Hui Lyu Guanmin Jiang Danyang Chen Sanbao Ruan Shuang Liu Lukun Zhou Minqiang Yang Shanshan Zeng Zhi-Min He Hong-Sheng Wang Hong-Sheng Li Guopei Zheng Xiaolong Liu

Published in: Cancer research (2022)

GLUT4 upregulation by ALKBH5-mediated m6A demethylation induces glycolysis and resistance to HER2-targeted therapy and represents a potential therapeutic target for treating HER2-positive breast cancer.

Keyphrases

positive breast cancer
poor prognosis
cell proliferation
signaling pathway
risk assessment
climate change