Human Endogenous Retrovirus K Envelope in Spinal Fluid of Amyotrophic Lateral Sclerosis Is Toxic.
Joseph P SteinerMuzna BachaniNasir MalikCatherine DeMarinoWenxue LiKevon SampsonMyoung-Hwa LeeJeffery KowalakManju BhaskarTara Doucet-O'HareMarta Garcia-MontojoMaria CowenBryan SmithLauren Bowen ReomaJulie MedinaJoanna BrunelJustine PierquinBenjamin CharvetHervé PerronAvindra NathPublished in: Annals of neurology (2022)
HERV-K Env is released extracellularly in ALS and causes neurotoxicity via a novel mechanism. Present results pave the way for new treatment strategies in sporadic ALS. ANN NEUROL 2022;92:545-561.