Impact of age-related T cell dynamics on the identification of biomarkers predictive of immunotherapy discontinuation: a prospective cohort study.

Jason E GallowayAndrea M HolderbaumNamrata AryaSuohui ZhangMichael S BodnarRuthann NormanWilliam E CarsonLianbo YuKari L KendraChristin E Burd

Published in: Aging and cancer (2020)

Correlations between transcriptional markers of PBTL composition and chronologic age are disrupted in MM. Correcting for normal, age-related trends in biomarker expression unveils new biomarker candidates predictive of ICI outcomes.

Keyphrases

poor prognosis
gene expression
transcription factor
type diabetes
long non coding rna
bioinformatics analysis
oxidative stress
insulin resistance