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How big is the little brain in the gut? Neuronal numbers in the enteric nervous system of mice, Guinea pig, and human.

Klaus MichelBirgit KuchSophie DenglerIhsan Ekin DemirFlorian ZellerMichael Schemann
Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2022)
This study reports the first comprehensive nerve cell count in mice, guinea pig, and human ENS. Neuronal densities were comparable between the three species and the differences in the total numbers of enteric neurons are likely due to body size and intestinal length. The number of enteric neurons is comparable to the number of neurons in the spinal cord for all three species.
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