Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia.

Yoshitaka NishikawaTaro FunakoshiTakahiro HorimatsuShin'ichi MiyamotoTakeshi MatsubaraMotoko YanagitaShunsaku NakagawaAtsushi YonezawaKazuo MatsubaraManabu Muto

Published in: Cancer chemotherapy and pharmacology (2017)

We found increases of serum FBAL and FMA under the condition of hyperammonemia in the patient with ESRD during mFOLFOX6 plus bevacizumab therapy. This research supported the hypothesis that impairment of tricarboxylic acid (TCA) cycle by FMA would cause 5-FU-associated hyperammonemia.

Keyphrases

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case report
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locally advanced