Spatial transcriptomic analysis delineates epithelial and mesenchymal subpopulations and transition stages in childhood ependymoma.

Rui FuGregory A NorrisNicholas WillardAndrea M GriesingerKent A RiemondyVladimir AmaniEnrique GrimaldoFaith HarrisTodd C HankinsonSiddhartha MitraTimothy A RitzmannRichard R GrundyNicholas K ForemanAndrew M Donson

Published in: Neuro-oncology (2022)

These insights demonstrate the utility of spatial transcriptomics to advance our understanding of ependymoma biology, revealing a clearer picture of the cellular constituents of PFA, their interactions and influence on tumor progression.

Keyphrases

stem cells
poor prognosis
bone marrow