Mobile App Interventions for Parkinson's Disease, Multiple Sclerosis and Stroke: A Systematic Literature Review.
Andreas TriantafyllidisSofia SegkouliStelios ZygourisChristina MichailidouKonstantinos AvgerinakisEvaggelia FappaSophia VassiliadesAnastasia BougeaNikos PapagiannakisIoannis KatakisEvangelos MathioudisAlexandru SoriciLidia BajenaruValentina TageoFrancesco CamonitaChristoniki Magga-NteveStefanos VrochidisLudovico PedullàGiampaolo BrichettoPanagiotis TsakanikasKonstantinos VotisDimitrios TzovarasPublished in: Sensors (Basel, Switzerland) (2023)
Central nervous system diseases (CNSDs) lead to significant disability worldwide. Mobile app interventions have recently shown the potential to facilitate monitoring and medical management of patients with CNSDs. In this direction, the characteristics of the mobile apps used in research studies and their level of clinical effectiveness need to be explored in order to advance the multidisciplinary research required in the field of mobile app interventions for CNSDs. A systematic review of mobile app interventions for three major CNSDs, i.e., Parkinson's disease (PD), multiple sclerosis (MS), and stroke, which impose significant burden on people and health care systems around the globe, is presented. A literature search in the bibliographic databases of PubMed and Scopus was performed. Identified studies were assessed in terms of quality, and synthesized according to target disease, mobile app characteristics, study design and outcomes. Overall, 21 studies were included in the review. A total of 3 studies targeted PD (14%), 4 studies targeted MS (19%), and 14 studies targeted stroke (67%). Most studies presented a weak-to-moderate methodological quality. Study samples were small, with 15 studies (71%) including less than 50 participants, and only 4 studies (19%) reporting a study duration of 6 months or more. The majority of the mobile apps focused on exercise and physical rehabilitation. In total, 16 studies (76%) reported positive outcomes related to physical activity and motor function, cognition, quality of life, and education, whereas 5 studies (24%) clearly reported no difference compared to usual care. Mobile app interventions are promising to improve outcomes concerning patient's physical activity, motor ability, cognition, quality of life and education for patients with PD, MS, and Stroke. However, rigorous studies are required to demonstrate robust evidence of their clinical effectiveness.
Keyphrases
- physical activity
- multiple sclerosis
- case control
- healthcare
- systematic review
- atrial fibrillation
- mass spectrometry
- randomized controlled trial
- adipose tissue
- quality improvement
- metabolic syndrome
- body mass index
- ms ms
- emergency department
- drug delivery
- palliative care
- machine learning
- high intensity
- artificial intelligence
- white matter
- chronic pain
- body composition
- glycemic control
- risk factors
- type diabetes