Login / Signup

Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer.

Yuan LiLiqing LuJian TuJing ZhangTing XiongWei FanJiaohong WangMeng LiYibu ChenJustin SteggerdaHui PengYongheng ChenTony W H LiZhi-Gang ZhouJosé M MatoJeffrey H AlbrechtTing LiuHeping YangShelly C Lu
Published in: Hepatology (Baltimore, Md.) (2020)
We have found a crosstalk between FOXM1/NF-κB and MAT1A. Up-regulation in FOXM1 lowers MAT1A, but raises NF-κB, expression, and this is a feed-forward loop that enhances tumorigenesis.
Keyphrases
  • signaling pathway
  • lps induced
  • transcription factor
  • pi k akt
  • nuclear factor
  • oxidative stress
  • poor prognosis
  • inflammatory response
  • long non coding rna