Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer.

Yuan LiLiqing LuJian TuJing ZhangTing XiongWei FanJiaohong WangMeng LiYibu ChenJustin SteggerdaHui PengYongheng ChenTony W H LiZhi-Gang ZhouJosé M MatoJeffrey H AlbrechtTing LiuHeping YangShelly C Lu

Published in: Hepatology (Baltimore, Md.) (2020)

We have found a crosstalk between FOXM1/NF-κB and MAT1A. Up-regulation in FOXM1 lowers MAT1A, but raises NF-κB, expression, and this is a feed-forward loop that enhances tumorigenesis.

Keyphrases

signaling pathway
lps induced
transcription factor
pi k akt
nuclear factor
oxidative stress
poor prognosis
inflammatory response
long non coding rna