Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells.

Donghee KimGa-Young NamEunhui SeoYoon Sin Oh

Published in: Journal of biomedical science (2022)

Collectively, the results demonstrated that the ROS/Akt-dependent downregulation of Smurf2 and the subsequent increase in ChREBP expression might be one of the mechanisms by which LPA induces mesangial cell fibrosis in DN.

Keyphrases

signaling pathway
cell proliferation
induced apoptosis
cell death
cell cycle arrest
diabetic nephropathy
dna damage
high glucose
reactive oxygen species
poor prognosis
pi k akt
single cell
cell therapy
liver fibrosis
endothelial cells
stem cells
binding protein
oxidative stress
long non coding rna