Targeting the centromedian thalamic nucleus for deep brain stimulation.
Aaron E L WarrenLinda J DalicWesley ThevathasanAnnie RotenKristian J BullussJohn ArcherPublished in: Journal of neurology, neurosurgery, and psychiatry (2020)
In the largest clinical trial of DBS undertaken in patients with LGS to date, we show that accurate targeting of the CM is achievable using 3T MP2RAGE MRI. Intraoperative MERs may provide additional localising features in some cases; however, their utility is limited by interpatient variability. Therapeutic effects of CM-DBS may be mediated via connectivity with brain networks that support diverse arousal, cognitive and sensorimotor processes.
Keyphrases
- deep brain stimulation
- parkinson disease
- resting state
- functional connectivity
- obsessive compulsive disorder
- clinical trial
- white matter
- cancer therapy
- magnetic resonance imaging
- sars cov
- contrast enhanced
- patients undergoing
- multiple sclerosis
- study protocol
- respiratory syndrome coronavirus
- randomized controlled trial
- magnetic resonance
- double blind
- phase ii
- diffusion weighted imaging
- mass spectrometry