Biomarkers of Pathological Complete Response to Neoadjuvant Immunotherapy in Mismatch Repair Deficiency Colorectal Cancer.

Jianxia Li Huabin Hu Ge Qin Fan Bai Xianrui Wu Haoxian Ke Jian-Wei Zhang Yuqian Xie Zehua Wu Yang Fu Hongbo Zheng Longlong Gong Zhi Xie Yan-Hong Deng

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Immune-associated transcriptomic features, particularly CD8+ T cells were associated with pCR response to ICI in dMMR CRC. Heterogeneity of TME within dMMR CRC may help to discriminate patients with complete response to neoadjuvant ICI.

Keyphrases

rectal cancer
locally advanced
single cell
lymph node
rna seq
squamous cell carcinoma
radiation therapy
replacement therapy
real time pcr