Molecular Signatures of Human Chronic Atrial Fibrillation in Primary Mitral Regurgitation.
Günseli Çubukçuoğlu DenizSerkan DurduYeşim DoğanEsra ErdemliHilal OzdagAhmet Ruchan AkarPublished in: Cardiovascular therapeutics (2021)
Atrial cardiomyocyte remodeling in persistent AFib is closely linked to alterations in gene expression profiles compared to SR in patients with primary MR. Study findings may lead to novel therapeutic targets. This trial is registered with ClinicalTrials.gov identifier: NCT00970034.
Keyphrases
- atrial fibrillation
- genome wide
- catheter ablation
- endothelial cells
- left atrial
- heart failure
- clinical trial
- left atrial appendage
- copy number
- phase iii
- study protocol
- oral anticoagulants
- magnetic resonance
- induced pluripotent stem cells
- direct oral anticoagulants
- magnetic resonance imaging
- computed tomography
- pluripotent stem cells
- percutaneous coronary intervention
- gene expression
- dna methylation
- mitral valve
- acute coronary syndrome
- open label