JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells.
Tereza KořánováLukáš DvořáčekDana GrebeňováKateřina KuželováPublished in: Pharmacological reports : PR (2024)
JR-AB2-011 affects leukemia/lymphoma cell metabolism via a mechanism independent of mTORC2.
Keyphrases
- acute myeloid leukemia
- induced apoptosis
- bone marrow
- endothelial cells
- cell cycle arrest
- single cell
- diffuse large b cell lymphoma
- cell proliferation
- cell therapy
- induced pluripotent stem cells
- endoplasmic reticulum stress
- pluripotent stem cells
- oxidative stress
- stem cells
- signaling pathway
- cell death
- mesenchymal stem cells
- pi k akt