An animal model of effects of nicotine exposure on endometrial receptivity and embryo implantation in pregnancy.
Yaşam Kemal AkpakYasemin ÇekmezAslı Erdoğan ÇakırNilay KaracaGonca BatmazSerdar GülşenEsra Tuştaş HaberalPublished in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2016)
No immunochemical effect was observed on integrin expression, which is a very important part of receptivity in an animal model created with pregnant rats that were transdermally exposed to nicotine. Our study demonstrated that the harmful effect of nicotine use before and pregnancy on implantation is limited at the level of integrin expression, in a dose-dependent manner and also by considering the method of administration.