Undescribed benzophenone and xanthones from cave-derived Streptomyces sp. CB09001.

Lin JiangJingxi XiangSaibin ZhuDanfeng TangBang GongHong PuYanwen DuanYong Huang

Published in: Natural product research (2020)

A new benzophenone huanglongmycin (HLM) D (1) and two new monomeric xanthones huanglongmycin E (2) and F (3), together with four known aromatic polyketides aloesaponarin II (4) and the previously isolated huanglongmycin A-C (5-7) were obtained from cave-derived Streptomyces sp. CB09001. The structures of 1-3 were established based on 1D, 2D NMR and HRMS data. Compounds 1-7 may be biosynthesized by a type II huanglongmycin polyketide synthase based on gene inactivation of hlmG encoding KSɑ in hlm gene cluster and their plausible biosynthetic mechanism was proposed.

Keyphrases

copy number
genome wide
high resolution
magnetic resonance
genome wide identification
electronic health record
dna methylation
amino acid
machine learning
transcription factor
high resolution mass spectrometry
solid state
data analysis