TERT promoter mutations increase tumor aggressiveness by altering TERT mRNA splicing in papillary thyroid carcinoma.

Ayaka SakoMichiko MatsuseVladimir A SaenkoAya TanakaRyota OtsuboMichi MoritaSayaka KubaEijun Nishihara Keiji SuzukiTomoo OgiAtsushi KawakamiNorisato Mitsutake

Published in: The Journal of clinical endocrinology and metabolism (2024)

These results provide evidence that the TERT-p mutations alter the expression of different TERT splice variants, which, in turn, associates with different tumor aggressiveness.

Keyphrases

poor prognosis
lymph node
gene expression
binding protein
lymph node metastasis
transcription factor
squamous cell carcinoma
sensitive detection
living cells
fluorescent probe
long non coding rna