Feasibility of conservative fluid administration and deresuscitation compared with usual care in critical illness: the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) randomised clinical trial.
Jonathan A SilversidesRoss McMullanLydia M EmersonIan BradburyJonathan Bannard-SmithTamás SzakmanyJohn TrinderAnthony J RostronPaul JohnstonAndrew J FergusonAndrew J BoyleBronagh BlackwoodJohn C MarshallDaniel Francis McAuleyPublished in: Intensive care medicine (2021)
A strategy of conservative fluid administration and active deresuscitation is feasible, reduces fluid balance compared with usual care, and may cause benefit or harm. In view of wide variations in contemporary clinical practice, large, adequately powered trials investigating the clinical effectiveness of conservative fluid strategies in critically ill patients are warranted.