Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications.
Tasmia AlamNathan KirkEmily HirschMargaret Briggs-GowanLauren S WakschlagAmy Krain RoyJillian Lee WigginsPublished in: International journal of methods in psychiatric research (2023)
Characterizing the normal: abnormal spectrum of irritability in preadolescence advances application of Research Domain Criteria methods to this developmental period. This foundational work yielded two developmentally specified tools for irritability characterization in preadolescence: a nuanced dimensional scale to precisely characterize the full normal-abnormal irritability spectrum, and a pragmatic, clinically optimized screener suitable for real world use. Future application in mechanistic and clinical studies will be important for establishing validity and incremental utility.