Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus Penicillium sclerotiorum cib-411.
Jia-Lin TangZong-Yuan ZhouTao YangCan YaoLin-Wei WuGuo-You LiPublished in: Journal of agricultural and food chemistry (2019)
Nine new azaphilone alkaloids, penazaphilones A-I (1-9), were isolated from the solid fermented rice culture of Penicillium sclerotiorum cib-411. The structures of compounds 1-9 were elucidated based on HRESIMS, NMR, and CD spectroscopic data. The structures of 5 and 8 were confirmed by X-ray crystallographic analyses. Biological evaluation showed that compounds 1, 5, 6, and 8 inhibited the production of nitric oxide (NO) on RAW 264.7 cells stimulated by lipopolysaccharide with IC50 values of 15.29, 9.34, 9.50, and 7.05 μM, respectively. Meanwhile, they did not exhibit obvious cytotoxicity at a concentration of 50.0 μM.
Keyphrases
- high resolution
- nitric oxide
- induced apoptosis
- cell cycle arrest
- molecular docking
- magnetic resonance
- inflammatory response
- toll like receptor
- electronic health record
- big data
- mass spectrometry
- hydrogen peroxide
- signaling pathway
- cell death
- magnetic resonance imaging
- computed tomography
- oxidative stress
- immune response
- machine learning
- cell proliferation
- lactic acid
- nk cells