The Antagonist Effect of Arachidonic Acid on GLUT4 Gene Expression by Nuclear Receptor Type II Regulation.
Inmaculada Moreno-SantosSara Garcia-SerranoHatim BoughanemLourdes Garrido-SanchezFrancisco José TinahonesEduardo Garcia-FuentesManuel Macias-GonzálezPublished in: International journal of molecular sciences (2019)
Our study suggests a dysregulation of LXR-α and GLUT4 expression in VAT of morbidly obese individuals. FA profiles in VAT could elucidate their possible role in lipolysis and adipogenesis. Finally, AA binds to PPAR-γ2 to activate the expression of GLUT4 in the HepG2 cell line, showing an alternative insulin-independent activation of GLUT4.