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The Antagonist Effect of Arachidonic Acid on GLUT4 Gene Expression by Nuclear Receptor Type II Regulation.

Inmaculada Moreno-SantosSara Garcia-SerranoHatim BoughanemLourdes Garrido-SanchezFrancisco José TinahonesEduardo Garcia-FuentesManuel Macias-González
Published in: International journal of molecular sciences (2019)
Our study suggests a dysregulation of LXR-α and GLUT4 expression in VAT of morbidly obese individuals. FA profiles in VAT could elucidate their possible role in lipolysis and adipogenesis. Finally, AA binds to PPAR-γ2 to activate the expression of GLUT4 in the HepG2 cell line, showing an alternative insulin-independent activation of GLUT4.
Keyphrases
  • gene expression
  • poor prognosis
  • type diabetes
  • adipose tissue
  • obese patients
  • binding protein
  • bariatric surgery
  • dna methylation
  • metabolic syndrome
  • weight loss
  • skeletal muscle
  • glycemic control