The Antagonist Effect of Arachidonic Acid on GLUT4 Gene Expression by Nuclear Receptor Type II Regulation.

Inmaculada Moreno-SantosSara Garcia-SerranoHatim BoughanemLourdes Garrido-SanchezFrancisco José TinahonesEduardo Garcia-Fuentes Manuel Macias-González

Published in: International journal of molecular sciences (2019)

Our study suggests a dysregulation of LXR-α and GLUT4 expression in VAT of morbidly obese individuals. FA profiles in VAT could elucidate their possible role in lipolysis and adipogenesis. Finally, AA binds to PPAR-γ2 to activate the expression of GLUT4 in the HepG2 cell line, showing an alternative insulin-independent activation of GLUT4.

Keyphrases

gene expression
poor prognosis
type diabetes
adipose tissue
obese patients
binding protein
bariatric surgery
dna methylation
metabolic syndrome
weight loss
skeletal muscle
glycemic control