The Impact of DNA Methylation on IL6 mRNA Levels in Hematinic Deficiency and Atopy-Associated Recurrent Aphthous Stomatitis Patients.

Nanan Nur'aeny Dida Akhmad Gurnida Oki Suwarsa Irna Sufiawati

Published in: International journal of dentistry (2021)

This study showed the upregulation of IL6 mRNA levels in RAS patients compared to control. DNA methylation in the present study is at sites 566-658, whereas the location of the IL6 promoter is at sites 1-1684. Thus, it would be necessary conducting some research at other CpG sites of IL6 promoter islands to determine the status of DNA methylation.

Keyphrases

dna methylation
end stage renal disease
gene expression
genome wide
newly diagnosed
chronic kidney disease
transcription factor
copy number
signaling pathway
poor prognosis
long non coding rna
smoking cessation
wild type