Human placental mesenchymal stromal cells alleviate intestinal oxidative damage in mice with graft-versus-host disease via CD73/adenosine/PI3K/Akt/GSK-3β axis.

Kaiyue HanFeifei WangXiaolin MaYunhua WuHengchao ZhangYaxuan ZhaoHua WangJunjie MaXiying Luan

Published in: Cellular signalling (2024)

The results suggested that hPMSC-mediated redox metabolism balance and promoted tight junction protein expression were achieved via CD73/ADO/PI3K/Akt/GSK-3β/Fyn/Nrf2 axis, by which alleviating intestinal oxidative injury in GVHD mice.

Keyphrases

pi k akt
signaling pathway
cell proliferation
cell cycle arrest
high fat diet induced
endothelial cells
bone marrow
blood brain barrier
wild type
type diabetes
allogeneic hematopoietic stem cell transplantation
pluripotent stem cells
skeletal muscle