Novel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer.

Geum-Lan HongKyung-Hyun KimYae-Ji KimHui-Ju LeeSung-Pil ChoSeung-Yun HanSeung Woo YangJong-Soo LeeShin-Kwang KangJae-Sung LimJu Young Jung

Published in: Biological research (2024)

Defective expression of LLGL2 leads to attenuation of EMT due to the upregulation of autophagy flux in PCa. Our results suggest that LLGL2 is a novel target for alleviating PCa via the regulation of autophagy.

Keyphrases

epithelial mesenchymal transition
signaling pathway
prostate cancer
cell death
endoplasmic reticulum stress
poor prognosis
oxidative stress
transforming growth factor
radical prostatectomy
long non coding rna