Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis.

Victoria OsinskiAmritha YellamilliMaria M Firulyova Michael J ZhangAlyssa L PeckJennifer L Auger Jessica L Faragher Aubyn Marath Rochus K VoellerTimothy D O'ConnellKonstantin Zaitsev Bryce A Binstadt

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

These studies reveal a novel mode of inflammation-associated, VEGFR3-dependent postnatal lymphangiogenesis in murine autoimmune valvular carditis, with similarities to human rheumatic heart disease.

Keyphrases

atrial fibrillation
multiple sclerosis
endothelial cells
vascular endothelial growth factor
oxidative stress
rheumatoid arthritis
aortic valve
preterm infants
lymph node
oral anticoagulants
genome wide
induced pluripotent stem cells
single cell
pluripotent stem cells
gene expression
case control