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Single-drug versus combination antimicrobial therapy in critically ill patients with hospital-acquired pneumonia and ventilator-associated pneumonia due to Gram-negative pathogens: a multicenter retrospective cohort study.

François BarbierClaire DupuisNiccolò BuettiCarole SchwebelÉlie AzoulayLaurent ArgaudYves CohenVivien Hong Tuan HaMarc GainnierShidasp SiamiJean-Marie ForelChristophe AdrieÉtienne de MontmollinJean ReignierStéphane RucklyJean-Ralph ZaharJean-François Timsitnull null
Published in: Critical care (London, England) (2024)
Initial combination therapy exerts no independent impact on Day-28 mortality, clinical cure rate at Day 14, and the hazard of death or AKI at Day 7 in critically ill patients with mono-bacterial HAP, vHAP or VAP due to Gram-negative bacteria.
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