Blockade of TGF-β signalling alleviates human adipose stem cell senescence induced by native ECM in obesity visceral white adipose tissue.
Xueya HanWeihong LiXu HeXin LuYu ZhangYaqiong LiGuoyun BiXuqing MaXiaowu HuangRixing BaiHaiyan ZhangPublished in: Stem cell research & therapy (2023)
Native ECM in obesity vWAT initiates hASC senescence through TGF-β1-mediated mitochondrial dysfunction. These data provide a key mechanism for understanding the importance of cell-ECM interactions in hASCs senescence in obesity.
Keyphrases
- insulin resistance
- adipose tissue
- endothelial cells
- metabolic syndrome
- high fat diet induced
- weight loss
- stem cells
- type diabetes
- dna damage
- high fat diet
- skeletal muscle
- weight gain
- transforming growth factor
- stress induced
- electronic health record
- single cell
- body mass index
- physical activity
- epithelial mesenchymal transition
- mesenchymal stem cells
- pluripotent stem cells