RAGE Ablation Attenuates Glioma Progression and Enhances Tumor Immune Responses by Suppressing Galectin-3 Expression.

Ian Y ZhangShunan LiuLeying ZhangRongrui LiangQinxiao FangJie ZhaoLyuzhi RenEric F MedinaAleksandr FilippovKimberley-Jane BonjocAmmar ChaudhryMojtaba DayyaniAndrea H BildBenham Badie

Published in: Neuro-oncology (2022)

We demonstrated that intracellular RAGE ablation suppresses multiple cellular pathways that are important in glioma progression, invasion, and immune escape. These findings strongly support the development of RAGE ablation as a treatment strategy for malignant gliomas.

Keyphrases

immune response
radiofrequency ablation
poor prognosis
catheter ablation
high grade
cell migration
toll like receptor
binding protein
inflammatory response