A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice.

Young-Jin JeongHae-Ri LeeSun-Ae ParkJoong-Woon LeeLee Kyung KimHee Jung KimJae Hong SeoTae-Hwe Heo

Published in: Pharmacological reports : PR (2024)

This study demonstrated that IA-0130 suppressed colitis progression by inhibiting the gp130 signaling pathway and expression of pro-inflammatory cytokines, and maintaining TJ integrity.

Keyphrases

signaling pathway
poor prognosis
pi k akt
epithelial mesenchymal transition
induced apoptosis
anti inflammatory
oxidative stress
cell proliferation
ulcerative colitis
insulin resistance