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Copper-catalyzed intramolecular dearomative aza-Wacker reaction of indole.

Bi WangRen-Xiao LiangZhen-Lu ShenYi-Xia Jia
Published in: Chemical communications (Cambridge, England) (2024)
Herein, we describe a copper-catalyzed intramolecular dearomative amination of indoles via a formal aza-Wacker reaction. This protocol provides an efficient method to access aza-polycyclic indoline molecules bearing exocyclic CC bonds in moderate to excellent yields in the presence of molecular oxygen as an oxidant. It is worth noting that indolin-3-ones are achieved when employing C3-non-substituted indoles as substrates.
Keyphrases
  • randomized controlled trial
  • molecular docking
  • electron transfer
  • quantum dots