Monocytic MDSC as a source of immunosuppressive cytokines in chronic lymphocytic leukemia (CLL) microenvironment.
Agnieszka A Bojarska-JunakAgnieszka Bojarska-JunakPublished in: Folia histochemica et cytobiologica (2020)
In conclusion, we have shown that an increased percentage of M-MDSC cells producing IL-10 and TGF-β1 in CLL patients may be associated with the suppression of the immune response against CLL. It can be assumed that the increased percentage of M-MDSC with an intracellular expression of IL-10 and TGF-β1 may be used in the future as the factor defining the group of patients with shorter time to onset of treatment.
Keyphrases
- chronic lymphocytic leukemia
- immune response
- end stage renal disease
- ejection fraction
- transforming growth factor
- induced apoptosis
- stem cells
- poor prognosis
- chronic kidney disease
- prognostic factors
- cell cycle arrest
- peritoneal dialysis
- oxidative stress
- patient reported outcomes
- cell death
- dendritic cells
- binding protein
- combination therapy
- signaling pathway
- smoking cessation
- pi k akt