Acetylshikonin promoting PI3K/Akt pathway and inhibiting SOX4 expression to delay intervertebral disc degeneration and low back pain.

Yuming HuangLinchuan LeiZhuoyang ZhaoZemin LiHua WangShunlun ChenJinjian ZhengGuowei JiangXingyu GuoJiamin LiJianru WangZhaomin ZhengFan Chen

Published in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society (2023)

Acetylshikonin delays IVDD-induced LBP by inhibiting SOX4 expression through the PI3K/Akt pathway. These findings offer potential therapeutic targets for future treatments. This article is protected by copyright. All rights reserved.

Keyphrases

poor prognosis
transcription factor
stem cells
signaling pathway
binding protein
diabetic rats
oxidative stress
drug induced
endothelial cells
human health