Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice.
Frank H SchaftenaarAndrea D van DamGerjan de BruinMarie A C DepuydtJill de MolJacob AmersfoortHidde DounaMenno MeijerMara J KrönerPeter J van SantbrinkMireia N A Bernabé KleijnGijs H M van PuijveldeBogdan I FloreaBram SlütterAmanda C FoksIlze BotPatrick C N RensenJohan KuiperPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
We propose that immunoproteasomal inhibition reduces 3 major causes underlying cardiovascular disease, dyslipidemia, metabolic syndrome, and inflammation and is a new target in drug development for atherosclerosis treatment.