Impact of surfactant when utilized during pediatric cardiac surgery admissions: analysis of a nationwide database.
Saúl FloresEnrique G VillarrealBrian LeeRaysa Morales-DemoriJuan S FariasMubbasheer AhmedRohit S LoombaFabio SavorgnanPublished in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2021)
Surfactant administration during pediatric cardiac surgery admissions is independently associated with a sixfold increase in inpatient mortality. It is likely that these findings are mediated by augmentation of the decrease in pulmonary vascular resistance and a subsequent decrease in systemic blood flow in the setting of parallel circulation. Surfactant should be administered with special consideration in neonates with cardiac disease and may be best avoided in those with parallel circulation.