Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E.

Jérôme RobertEmily B ButtonEmma M MartinLuke McAlaryZoe GiddenMegan GilmourGuilaine BoyceTara M CaffreyAndrew AgbayAmanda ClarkJudith M SilvermanNeil R CashmanCheryl L Wellington

Published in: Molecular neurodegeneration (2020)

The findings in this study identify new mechanisms by which circulating HDL, particularly HDL particles enriched in apoE, may provide vascular resilience to Aβ and shed new light on a potential role of peripherally-acting apoE in AD.

Keyphrases

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