Towards an in vitro fibrogenesis model of human vocal fold scarring.
M GrauppB RinnerM T FrischG WeissJ FuchsM SundlA El-HeliebiG MoserL P KamolzMichael KarbienerM GugatschkaPublished in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2018)
Based on the principles of MMC we could successfully establish a laryngeal fibrogenesis model employing hVFF. Our finding of dose-dependent HGF effects is important before going into clinical trials in humans and has never been shown before. Our model provides a novel option to screen various potential antifibrotic compounds under standardized conditions in a short time.