A rodent model of human dose-equivalent progestin-only implantable contraception.

Heather C M Allaway Roger A Pierson Jesse Invik Susan A Bloomfield

Published in: Reproductive biology and endocrinology : RB&E (2021)

Assessment of estrus cyclicity indicated a dose-response relationship in the shift to a larger number of acyclic rats and longer in duration spent in the diestrus phase. Therefore, each dose in this model mimics some of the changes observed in the ovaries of women using ENG LARC and provides an opportunity for investigating the impacts on non-reproductive tissues in the future.

Keyphrases

endothelial cells
polycystic ovary syndrome
gene expression
type diabetes
current status
induced pluripotent stem cells
metabolic syndrome
pluripotent stem cells
insulin resistance
skeletal muscle