Clinical consequences of off-label reduced dosing of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: a systematic review and meta-analysis.
Linda P T JoostenRosanne van MaanenCarline J van den DriesFrans H RuttenArno W HoesChristopher B GrangerMartin E W HemelsGeert-Jan GeersingSander van DoornPublished in: Open heart (2023)
This meta-analysis shows no statistically significant increased risk of stroke/thromboembolism, nor a decreased bleeding risk, nor a difference in risk of all-cause mortality in patients with OLRD of NOACs. Future research may focus on differences between NOACs.