Enhanced Cell-Chip Coupling by Rapid Femtosecond Laser Patterning of Soft PEDOT:PSS Biointerfaces.
Francesca SantoroYoeri van de BurgtScott Tom KeeneBianxiao CuiAlberto SalleoPublished in: ACS applied materials & interfaces (2017)
Interfacing soft materials with biological systems holds considerable promise for both biosensors and recording live cells. However, the interface between cells and organic substrates is not well studied, despite its crucial role in the effectiveness of the device. Furthermore, well-known cell adhesion enhancers, such as microgrooves, have not been implemented on these surfaces. Here, we present a nanoscale characterization of the cell-substrate interface for 3D laser-patterned organic electrodes by combining electrochemical impedance spectroscopy (EIS) and scanning electron microscopy/focused ion beam (SEM/FIB). We demonstrate that introducing 3D micropatterned grooves on organic surfaces enhances the cell adhesion of electrogenic cells.
Keyphrases
- cell adhesion
- induced apoptosis
- electron microscopy
- cell cycle arrest
- single cell
- randomized controlled trial
- signaling pathway
- systematic review
- endoplasmic reticulum stress
- cell death
- gold nanoparticles
- magnetic resonance imaging
- cell therapy
- bone marrow
- oxidative stress
- mesenchymal stem cells
- escherichia coli
- solid state
- amino acid
- liver fibrosis
- biofilm formation
- high speed